Dr Luke Clifton

Biological Sample Specialist

Location R 3, 1. 27
Rutherford Appleton Laboratory
E-mail luke.clifton@stfc.ac.uk
Telephone (office) +44 (0) 1235 446060

Introduction and profile

Role

My role is to support ISIS facility users by assisting in the optimisation of biological samples for neutron scattering experiments, providing assistance during instrument beam-time and with neutron scattering data analysis. I also work on the development and implementation new and improved approaches in the application of neutron scattering techniques to biological sciences.

Research and development interests

My research interests are in the relationship between the structure and activity of integral membrane and membrane/lipid binding proteins, with an emphasis on the use of neutron scattering techniques in these studies.

Publications

  1. Clifton LA, Lad MD, Green RJ, and Frazier RA. Single amino acid substitutions in puroindoline-b mutants influence lipid binding properties. Biochemistry 2007 Feb 27; 46(8) 2260-6.
  1. Lad MD, Birembaut F, Clifton LA, Frazier RA, Webster JR, and Green RJ. Antimicrobial peptide-lipid binding interactions and binding selectivity. Biophys J 2007 May 15; 92(10) 3575-86.
  1. Castelletto V, Krysmann MJ, Clifton LA, Lambourne J, and Noirez L. Structural study of BSA/poly(ethylene glycol) lipid conjugate complexes. J Phys Chem B 2007 Sep 27; 111(38) 11330-6.
  1. Clifton LA, Green RJ, and Frazier RA. Puroindoline-b mutations control the lipid binding interactions in mixed puroindoline-a:puroindoline-b systems. Biochemistry 2007 Dec 4; 46(48) 13929-37
  1. Castelletto V, Hamley IW, Clifton LA, and Green RJ. Osmotic pressure and aggregate shape in BSA/poly(ethylene glycol)-lipid/Dextran solutions. Biophys Chem 2008 Apr; 134(1-2) 34-8.

  2.  Clifton LA, Green RJ, Hughes AV, and Frazier RA, J. Phys, Interfacial Structure of Wild-Type and Mutant Forms of Puroindoline-b Bound to DPPG Monolayers, J. Phys. Chem. B 2008, 112, 15907–15913.

  3.  Krysmann MJ, Castelletto V, McKendrick JE, Clifton LA, Hamley IW, Harris PJF, and King SM. Self-Assembly of Peptide Nanotubes in an Organic Solvent. Langmuir 2008, 24, 8158-8162.

  4. Clifton LA, Neylon C,Terry AE, Dicko IC and Diddens IA. Characterizing Biomaterial Complexity, 2009, Materials Today.

  5. Dobreva, M. A., Frazier, R. A., Mueller-Harvey, I., Clifton, L. A., Gea, A., Green, R. J. Binding of Pentagalloyl Glucose to Two Globular Proteins Occurs via Multiple Surface Sites Biomacromolecules, 2011, 12 (3), pp 710–715, 2011.

  6. Clifton, L. A., Sanders M. R., Castelletto, V., Rogers S. E., Heenan R. K., Neylon C., Frazier, R. A, and Green, R. J.  Puroindoline-a, a Lipid Binding Protein from Common Wheat, Spontaneously Forms Prolate Protein Micelles in Solution, Phys. Chem. Chem. Phys., 2011, 13, 8881-8888.

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