The longer range hierarchical structure of synthetic and natural fibres, bones, or scaffolded materials, requires the 2D scattering capability of ZOOM. Location of water is a key use for neutrons, as is the study of samples that are sensitive to X-ray damage. For larger proteins or biomolecular complexes the wide simultaneous Q range available on ZOOM would enhance modelling of molecular shapes. This would include following the stages of polypeptide aggregation in amyloid plaque formation and many similar processes of medical importance. To make best use of focussing to reach the smallest Q’s, samples up to ~ 40 mm diameter would be required, which in some cases could be restrictive. Focussing at the sample would provide a realistic method for scanning-SANS (and neutron transmission) from bio-structures and bio-fibres on a < ~1mm scale, with all the advantages of contrast variation and still a fairly wide simultaneous Q range to cover the typically different length scales of both longitudinal and transverse structure.