Scientists have identified a potential new target for the development of anticancer drugs against metastatic breast cancer. In a novel series of experiments, whole human cells were analysed with neutrons for the first time and the results revealed that the water within cells responded to the widely used chemotherapy drug, cisplatin. This study highlights the potential of intracellular water as an additional target for the development of new anticancer drugs, which could lead to higher efficiency, fewer cases of acquired resistance and less deleterious secondary drug effects in the treatment of breast cancer.
Photochemistry is a chemical reaction caused by the absorption of light (photons). It underpins a large range of important biological and industrial processes, from photosynthesis in plants through a host of chemical engineering applications – for example, the manufacture of the antimalarial drug artemisinin. Excitations in molecules also play a key role in devices – for example organic LEDs and organic photovoltaic cells. However, the fundamental science that underpins many of the photophysical and photochemical processes is not understood on the atomic scale.
Water is vital to life on planet Earth. We see it every day, we drink and bathe in it; we use it to clean, cook, grow crops, provide energy, and we complain when it falls from the skies. It makes up around two thirds of a healthy human, and covers 70% of the Earth’s surface. Yet, despite its importance in everyday life, water has managed to retain some of its mystery.
Less than 2% of small molecules, including therapeutics, are able to cross the blood-brain barrier (BBB) and reach the brain from the bloodstream. The blood-brain barrier is a semi-permeable barrier that separates the extracellular fluid surrounding the brain from circulating blood. Separating the brain from the bloodstream, it protects the brain against any sort of toxins in the blood. Its protective nature is because of its high selectivity; however, this also means it is difficult to deliver therapeutics to the brain.