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​Dr Najet Mahmoudi, PhD

Najet is the SANS2D instrument responsible within the Small-Angle Neutron Scattering Group​ at ISIS and focuses on developing capabilities and applications of SANS in life sciences.

She joined ISIS in 2016 as a SANS instrument scientist in the Large Scale Structures Group, and in 2019 she became the instrument responsible for SANS2D.

Najet graduated with an Engineer's and MSci degrees from the University of Carthage (Tunisia) and gained her PhD from the Biology and Chemistry Doctoral School at the University of Nantes (France), studying the impact of structure on the interfacial properties of self-assembled proteins. She then went on to do postdoctoral work in protein biophysical chemistry at the University of Fribourg (Adolphe Merkle Institute, Switzerland), Cambridge University (Cavendish Laboratory, Swiss National Science Foundation Fellowship) and the University of Lund (Physical Chemistry Department, Sweden).

She is interested in understanding the structural properties of biological soft matter systems such as protein complexes and hydrogels, and drug delivery systems like lipid nanoparticles. She works very collaboratively with colleagues in academia and industry and is particularly interested in combining in-situ investigation of dynamics and mechanical properties to SANS using techniques like dynamic light scattering and rheology (DLS-SANS and Rheo-SANS)5 and size-exclusion chromatography (SEC-SANS).    

A full list of Najet's publications can be found here. Selected publications are listed below:

  1. MDG Hughes, S Cussons, N Mahmoudi, DJ Brockwell, L Dougan. Tuning Protein Hydrogel Mechanics through Modulation of Nanoscale Unfolding and Entanglement in Postgelation Relaxation. ACS Nano, 2022, 16, 10667–10678.
  2. B Shriky, N Mahmoudi, A Kelly, M Isreb, T Gough. The effect of PEO homopolymers on the behaviours and structural evolution of Pluronic F127 Smart Hydrogels for Controlled Drug Delivery Systems. Colloids and Surfaces A: Physicochemical and Engineering Aspects, 2022, 645, 128842.
  3. F Foglia, Q Berrod, AJ Clancy, K Smith, G Gebel, V García Sakai, M Appel, J-M Zanotti, M Tyagi, N Mahmoudi, TS Miller, JR Varcoe, A Periasamy, DJL Brett, PR Shearing, S Lyonnard, PF McMillan. Disentangling water, ion and polymer dynamics in an anion exchange membrane. Nature Materials, 2022, 21, 555-563.
  4. L Cui, MR Hunter, S Sonzini, S Pereira, SM Romanelli, K Liu, W Li, L Liang, B Yang, N Mahmoudi, AS Desai. Mechanistic studies of an automated lipid nanoparticle reveal critical pharmaceutical properties associated with enhanced mRNA functional delivery in vitro and in vivo. Small, 2022, 18, 2105832.
  5. V Nigro, R Angelini, S King, S Franco, E Buratti, F Bomboi, N Mahmoudi, F Corvasce, R Scaccia, A Church, T Charleston, B Ruzicka. Apparatus for simultaneous dynamic light scattering–small angle neutron scattering investigations of dynamics and structure in soft matter. Review of Scientific Instruments, 2021, 92, 023907.
  6. RC Oliver, W Potrzebowski, SM Najibi, MN Pedersen, L Arleth, N Mahmoudi, I André. Assembly of capsids from hepatitis B virus core protein progresses through highly populated intermediates in the presence and absence of RNA. ACS Nano, 2020, 14, 10226-10238.
  7. S Datta, Y Kato, S Higashiharaguchi, K Aratsu, A Isobe, T Saito, DD Prabhu, Y Kitamoto, MJ Hollamby, AJ Smith, R Dalgliesh, N Mahmoudi, L Pesce, C Perego, GM Pavan, S Yagai. Self-assembled poly-catenanes from supramolecular toroidal building blocks. Nature, 2020, 583, 400-405.
  8. N König, L Willner, V Pipich, N Mahmoudi, R Lund. Tale of Two Tails: Molecular Exchange Kinetics of Telechelic Polymer Micelles. Physical review letters, 2020, 124, 197801.
  9. D Ahmadi, N Mahmoudi, P Li, K Ma, J Doutch, F Foglia, RK Heenan, D Barlow, MJ Lawrence. Revealing the hidden details of nanostructure in a pharmaceutical cream. Scientific reports, 2020, 10, 1-12.
  10. LA Clifton, SCL Hall, N Mahmoudi, TJ Knowles, F Heinrich, JH Lakey. Structural investigations of protein–lipid complexes using neutron scattering. Lipid-Protein Interactions, 2019, 201-251.
  11. N Mahmoudi, A Stradner. Structural arrest and dynamic localization in biocolloidal gels. Soft Matter, 2017, 13, 4629-4635.
  12. S Bucciarelli, N Mahmoudi, L Casal-Dujat, M Jéhannin, C Jud, A Stradner. Extended law of corresponding states applied to solvent isotope effect on a globular protein. The journal of physical chemistry letters, 2016, 7, 1610-1615.